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While some individuals may experience mild digestive side effects such as nausea, bloating, diarrhea, or constipation, these are generally uncommon and typically mild

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Pain scores improved by approximately 76% on the WOMAC scale, and more than 12% of Retatrutide-treated participants reported complete freedom from knee pain at week 68, compared to 4.2% on placebo

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The best defense is proactive: encourage strength training and adequate protein from the very beginning so that patients preserve muscle while they lose weight

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That means reaching at least 10mg (ideally 15mg) and staying at that dose for a minimum of 12 weeks before concluding it has failed

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Substantial weight loss may reduce knee loading and improve symptoms, but clinically relevant loss of lean mass may worsen sarcopenia, quadriceps weakness, balance, walking capacity, and postoperative recovery

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