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Tumor cells can evade immune surveillance by overexpression of PD-L1 or activation of PD-L1/PD-1 signaling pathway, and high expression of PD-L1 in HCC tissues has been demonstrated

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Semin Cancer Biol 59:187207

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For miscarriage risk, women with obesity or diabetes face a 25-30% baseline risk compared to 10-15% in the general population