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Sunand K, Mohan GK, Bakshi V (2021) Synergetic potential of combination probiotic complex with phytopharmaceuticals in valproic acid induced autism: prenatal model

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IN THIS EPISODE, YOU WILL LEARN: How his struggle with inflammatory bowel disease led Nick to realize that the evidence-based care of western medicine is not always the best type of care, and how a ketogenic diet saved his life How a recent study highlighted several major physical issues statins cause, yet it went largely unnoticed in medicine and the media The need for clinicians to inform their patients about the potential side effects of their medications How physicians tend to ignore evidence in favor of one-sided messaging that erodes trust and undermines informed care The importance of remaining curious and acknowledging that what you learned initially might be incorrect How technological advances will make personalized medicine the future of healthcare The limitations of traditional one-size-fits-all randomized controlled trials The sub-phenotypes of type 2 diabetes How enzyme inhibitors (like statins) disrupt the gut microbiome How metabolic health and oxidative stress affect Lp(a), and how vitamin C can potentially reduce its impact Bio: Nick Norwitz Nick Norwitz, MD, PhD, is a researcher-educator whose mission is to Make Metabolic Health Mainstream. He graduated Valedictorian from Dartmouth College, majoring in Cell Biology and Biochemistry, before completing his PhD in Metabolism at the University of Oxford and his MD at Harvard Medical School

Esculetin (ESC) exhibits diverse anticancer mechanisms across different malignancies.(Top left)In hepatocellular carcinoma (HCC), ESC induces ferroptosis through multiple pathways: promoting ferritinophagy-mediated iron release from ferritin, suppressing antioxidant defenses (SLC7A11, GPX4, Nrf2), enhancing ACSL4-dependent lipid peroxidation, and increasing malondialdehyde (MDA) levels, ultimately leading to iron-dependent cell death.(Top right)In colorectal cancer (CRC), ESC disrupts copper homeostasis by upregulating the copper importer SLC31A1 (CTR1) and downregulating the copper exporter ATP7B, resulting in toxic copper accumulation and cuproptosis

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"Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport"