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Conclusion In addition to the well-established role of GLP-1 to improve glucose homeostasis, GLP-1R agonism has beneficial effects on body weight reduction
Sources SURMOUNT-1 trial (Jastreboff et al., New England Journal of Medicine, 2022) primary clinical trial reporting GI side-effect rates by dose for tirzepatide
Phentermine-topiramate and bupropion-naltroxene are less expensive, costing $100 to $200 for a 30-day supply without insurance (although they may be cheaper if your provider prescribes a generic version of these drugs)
Whilst it has a different mechanism to GLP-1 receptor agonists, it can be used in patients with high cholesterol and may be appropriate for those who cannot tolerate or access injectable treatments
PlexusDx focuses on precision wellness by evaluating biomarker context and genetic predisposition patterns that may influence peptide responsiveness and guide more personalized conversations with your healthcare provider
Grunvald E, Shah R, Hernaez R, Chandar AK, Pickett-Blakely O et al (2022) AGA clinical practice guideline on Pharmacological interventions for adults with obesity
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