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NBDHEX simultaneously activates JNK and TRAF2, interfering with the effect of GST via two different pathways, leading to cell-cycle arrest and cell death

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Together, these limitations reveal a fundamental weakness in the translational pipeline: Preclinical models, often biologically reductionist and poorly representative of human pathology, remain inadequate to support the development of interventions with reproducible and clinically relevant neuroprotective effects

75% of the total amino acids in our regular diet and absorbed in the small intestine

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In reversed-phase HPLC (RP-HPLC), the peptide mixture is separated based on hydrophobicity as it passes through a C18 or C8 column