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Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cells
Ablation of either of these branches increases hepatic lipogenic gene expression and steatosis while leading to unresolved ER stress, characterized by sustained UPR activation and, in particular, elevated ATF4/CHOP signaling
Zhu et al., 2016)
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