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significantly downregulated the levels of Fabp4 in adipose tissue and Srebp1c , Nr1h3 in the liver, promoting triglyceride hydrolysis and fatty acid oxidation in adipose tissue and liver of obese mice, inhibiting the fatty acid synthesis pathway to improve lipid metabolism
Therefore, we have emphasized the crucial role of the CS and its fine-tuned regulation, which is both enzymatic- and miRNA-dependent, as the primary factor in metabolic cancer flexibility
2124) retained the consistent clustering of early versus late mutations compared to germline, as well as the preferential grouping of ctDNA samples with specific mutations, with differences likely the result of enhanced phylogenetic signal when combining these data
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