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After binding of its RSPO ligand, LGR5 forms a potentiating complex with the Wnt protein-bound frizzled receptor (FZD)/lipoprotein-related receptor 5/6 (LRP5/6) augmenting downstream Wnt signaling and enhancing Wnt target gene expression (7276)
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Adults: Take 1-2 capsules twice daily Children under 12 years of age: Take 1 capsule daily or twice daily
and N.D.P
For most people, these are most pronounced when they first start the medication or after a dose increase
For those at high risk of NAION, alternative treatment options for diabetes and weight management may be considered
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