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PT-141 was FDA-approved in 2019 under the brand name Vyleesi for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women, representing the first melanocortin receptor agonist approved for this indication
Pharmacology & Therapeutics, 2007, 113(3): 546-593
Myotube-derived exosomes participate in the transport of irisin and enter osteoblasts through vesicle-mediated endocytosis, which may serve as a novel mechanism for exercise to ameliorate osteoporosis
Future research should investigate long-term outcomes in high-risk populations, direct comparisons between physiological and pharmacological dosages, cost-effectiveness analyses, and adherence metrics to inform optimal strategies for the prevention and management of vitamin B12 deficiency
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doi: 10.1016/j.jstrokecerebrovasdis.2018.11.008 7 HuangYCaiXMaiWLiMHuY
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