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Routine monitoring of thyroid function may be considered Avoid use in patients with a history of medullary thyroid carcinoma Evaluate unexplained thyroid nodules promptly 11.2 Pancreatitis Risk and Clinical Vigilance Acute pancreatitis, though infrequent, represents a serious adverse event

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This makes them a dual-action therapy targeting both metabolic and inflammatory pathways

Cloning and site-directed mutagenesis All plasmids and primers for cloning and site-directed mutagenesis are listed as separate Supplementary Data

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Retatrutides three arms, GLP-1, GIP, and glucagon, all engage at low doses