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D., McDonough, J
The most frequently reported side effects were gastrointestinal side effects of mild-moderate intensity and were transient over time
The NEJM 2023 phase 2 trial enrolled adults with obesity (BMI 30 to 50) without type 2 diabetes and randomized them across multiple retatrutide dose levels versus placebo
Low levels of this neurotransmitter result in difficulty relaxing, and prolonged low levels can lead to anxiety, depression, insomnia and certain mood disorders
Someone already tolerating metformin may need a different starting strength than someone who previously had nausea or diarrhea
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