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Zampieri et al., 2012b)
Pharmacol Sci
MC5R appears to be expressed broadly across tissues, although its precise physiological role remains under investigation, with some studies suggesting involvement in exocrine related processes
Hydroxyurea-induced nail pigmentation in HIV patients
These melanogenesis studies established MT-1 as the most pharmacologically tractable reference agonist for MC1R-mediated pigmentation biology and provided the foundational characterisation of the MC1R-cAMP-MITF-tyrosinase signalling cascade
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