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One of the key challenges is the compensatory upregulation of other enzymes, such as TDO2, which can maintain kynurenine production in the presence of IDO1 inhibitors ( Figure 1B ) ( Figure 1C ), thereby reducing the likelihood of compensatory metabolic pathways sustaining kynurenine production ( Table 1 IDO1 and TDO therapies in clinical development

By contrast, vitamin B12 has prescription dosing schedules for deficiency

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