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Hydroxocobalamin 1mg intramuscular injections are prescription-only medicines in the UK, indicated for confirmed B12 deficiency or malabsorption conditions such as pernicious anaemia
But the study had a small sample, no control group, and self-reported symptom outcomes
If you're 50 or over, your doctor may recommend a B12 shot after a significant blood test
Some researchers keep a 5mg vial specifically for the first two weeks at 1mg (using just 20 units per dose), then switch to larger vials for the remainder of the protocol
For doses of 7.5mg or higher with a 5mg/ml concentration, many researchers find it more practical to switch to a higher concentration vial
Weekly injections are the standard recommendation for the first phase of treatment
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