Regardless of the specific technique, it is essential to define the observation window (what history is used) and the prediction horizon (what time frame is being predicted), and to train and test models using hard clinical end points to avoid data leakage and to keep the results clinically meaningful (105)
In real-world trials, fewer than 10% of patients discontinued both oral and injectable semaglutide due to side effects
The advent of the incretin era in T2D treatment has now provided therapeutic options that have shown little to no dependence on the liver for elimination
Especially in the beginning, but also when you titrate up to the next dose that depression can really worsen
Nucleic Acids Res 43, D345D356, doi: 10.1093/nar/gku1214 (2015)
Hepatic autography in uncontrolled experimental diabetes and its relationships to insulin and glucagon