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The SELECT trial (NEJM, 2023) demonstrated that semaglutide 2.4mg reduced major adverse cardiovascular events (MACE) by 20% in over 17,000 patients with overweight/obesity and established cardiovascular disease, without diabetes
A systematic review and meta-analysis of randomized clinical trial
10.1186/s12933-023-01738-2 166
Inhibitors of copper chaperones address the concern of other copper chelators in that they non-selectively bind other metal cations and produce toxic side effects (11)
To reduce side effects, clinicians typically begin at the lowest dose and increase slowly
The role of adjunctive exenatide therapy in pediatric type 1 diabetes
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