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For serious adverse events, the incidence of adverse effects was highest with liraglutide 3.0 mg, followed by liraglutide 1.8 mg, semaglutide 2.4 mg, and semaglutide 1.0 mg
The mechanistic argument is solid, the exact magnitude in humans is not
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(2025) mapped central GLP-1R circuits engaged by long-acting agonists, identifying hypothalamic and brainstem populations that mediate the appetite and body-weight effects observed in extended dosing windows [3]
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