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Broad Institute Connectivity Map analysis shows it influences approximately 6% of the human genome making this one of the most broadly active signaling peptides in published research

Phiel et al

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10.1186/s12905-022-02056-7 242 WuH.LiuQ.YangN.XuS

Diabetes Care, 32(1), 84-90

And as the authors further noted, The therapeutic scope of GLP-1 medicines extends beyond glycemic control and weight loss, with benefits evident in people with atherosclerotic heart disease, heart failure with preserved ejection fraction (HFpEF), peripheral artery disease, diabetic kidney disease, knee osteoarthritis, and obstructive sleep apnea (OSA). However, as the team further pointed out, the mechanisms by which GLP-1 medicines improve organ dysfunction remain incompletely understood. Drucker has been at the forefront of GLP-1 research since the 1980s when his pioneering discoveries helped lay the groundwork for the development of GLP-1 medicines