Potential concerns include effects on angiogenesis that theoretically could influence tumor development or progression, though preclinical studies show context-dependent effects that inhibit pathological angiogenesis in some tumor models
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Ru Q, Li Y, Chen L, Wu Y, Min J, Wang F
Confocal images were acquired with a Leica AOBS SP2 laser scanning confocal microscope (Leica, Heidelberg, Germany)
28 note to investors, William Blair analysts wrote that Applied Therapeutics suspects the CRL was related to the efficacy package as opposed to [chemistry, manufacturing and controls] or safety. Results from the Phase III ACTION-Galactosemia Kids study, unveiled in April 2023, showed that govorestat fell short of its primary efficacy endpoint, a composite of four clinical measures designed to assess various domains of galactosemia symptoms
In some cases, these conditions may exaggerate skin inflammation