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Biochem Pharmacol 76:15441553

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First, we documented that our siRNA approach reduced Mtpa mRNA levels by 76% and MTP protein by 67% in caSMCs and compared the results with those obtained with the negative control siRNA (Figure 7, A and B)

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4.3 Bone-targeted delivery systems Efficient delivery of therapeutic agents to bone tumors is complicated by the unique physiological features of bone tissue, including its dense mineralized matrix, low blood flow in certain regions, and the presence of the bone marrow niche (59)

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