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Probiotic potentials and protective effects of Ligilactobacillus animalis LA-1 against high-fat diet-induced obesity in mice
In this review, we synthesize clinical and preclinical evidence demonstrating that KP dysregulation constitutes a convergent mechanism linking stress, inflammation, excitotoxicity, and oxidative stress in MDD, and critically evaluate its potential as a source of biomarkers and therapeutic targets (see Fig
It is not a replacement for these medications but rather a different approach targeting a distinct metabolic pathway
In addition, proteomic analysis confirmed upregulation of collagen type I and decorin, consistent with dermal remodeling activity
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In obesity management, conventional interventions, such as lifestyle modification and traditional pharmacotherapy, demonstrate limited efficacy in patients with moderate to severe obesity, and sustained weight loss is difficult to achieve
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