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Disclosures The LEADER, SUSTAIN-6, REWIND, PIONEER 6, SELECT, SOUL, STEP-HFpEF (with and without diabetes), and FLOW trials were sponsored by Novo Nordisk
It was the first study to look at the effectiveness of pills rather than injectables, and while small, it was a double-blind, randomised, parallel-arm trial ie gold standard
The compound is currently in Phase 3 clinical trials and is not yet approved by the FDA or Health Canada
For example, short-chain fatty acids produced by probiotic fermentation stimulate intestinal cells to release GLP-1
No difference in the need for definitive therapy was observed
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