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UCK2 inhibitors are still in preclinical development, but are positioned in combination with 5FU or other cytotoxics that alter nucleotide pools

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We tested cell viability and cytotoxicity of the neurons in each group by 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di-phenytetrazoliumromide (MTT) and lactate dehydrogenase (LDH) assays

Agency reviewers concluded that the submitted information did not provide enough reliable evidence to show effectiveness for that use