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In dietinduced obese mice, NNMTi treatment significantly reduced liver weight, liver volume, and hepatic triglyceride levels, alleviated hepatic steatosis and inflammatory infiltration, downregulated inflammatory factors (such as TNF and IL6) and lipogenic genes (such as FAS), and upregulated lipolytic genes (such as ATGL) in the liver

The study emphasized that while AOD 9604 suggested promise in supporting cartilage regeneration, the exact mechanisms by which it exerts these impacts are not well understood

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DECIPHER (v2.6.0) was used to align sequences, and FastTree (v2.1.3) was used to generate a phylogenetic tree