The upregulation of SLC7A11 in glioblastoma (GBM) leads to heightened levels of extracellular glutamate, facilitating the proliferation, activation, and suppressive capabilities of regulatory T (Treg) cells, consequently fostering intratumoral immunosuppression (49)
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Lee, J.K., Lee, J.S., Park, H., Cha, Y.S., Yoon, C.S
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Post-treatment, the cells were washed with 1X phosphate-buffered saline and stained with 15 M DCFDA-H2 or 5 M MitoSOX for 15 min at 37 C
PubMed Glyceryl ascorbate derivatives (2GA16) demonstrated dose-dependent suppression of interleukin-33 expression and increased expression of filaggrin and involucrin in keratinocytes