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Protein level analysis demonstrated that irisin treatment significantly restored the expression of PGC-1 downstream target proteins, including UCP2, NRF1, and NRF2 (Fig

5d) therefore suggests a less efficient interaction between E170X mutants and HEDS-derived GSSEtOH in accordance with the scaffold model and the hypothesis that GSSEtOH formation is catalysed by ScGrx7

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FIGURE 2 3.1

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