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Zinc also regulates the endolysosomal tethering machinery through the HOPS complex, whose VPS18 and VPS41 subunits contain zinc-binding RING domains essential for heterodimer formation and complex stability, which is critical for autophagosomelysosome and endosomelysosome fusion 104

Sharp, intense, or worsening pain suggests potential complications like bowel obstruction

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Larson, Glucose levels and risk of dementia, N

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