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Studies have also shown that tirzepatide provides improvements in people with obstructive sleep apnea (OSA) and Zepbound was recently approved by the FDA for this indication

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It should be used with a reduced-calorie diet and increased physical activity

It functions as a negative allosteric regulator, reducing the affinity of oligomeric A and interfering with A-induced synaptic toxicity [57]

Qsymia, Contrave and orlistat are still options for some patients, even if they are not driving the cultural conversation the way GLP-1s are

355933-2011 & RGPIN 2016-06034)