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For weight loss specifically, Phase 2 trial data suggests retatrutide produces greater average weight loss (22-24%) compared to tirzepatide (18-22%) at maximum doses

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The antinociceptive impact of DSIP was negated by the opioid antagonist naloxone and was not observed in morphine-tolerant mice, suggesting that DSIP acts at the supraspinal level, possibly influencing opioid receptors [11]

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Dehydration is a common migraine trigger