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Well-designed controlled studies are needed to replicate these preliminary findings

doi:10.1001/jama.2021.1831 Lundgren JR, Janus C, Jensen SBK, et al

It can occur due to general anorectal muscular weakness as a result of chronic constipation, laxative use, severe hemorrhoids, rectal prolapse, or fecal impaction (UMMC 2014)

Mitochondria-targeted melatonin photorelease supports the presence of melatonin MT1 [PMID: 37572668] Laboratory literature summary: Mitochondria-targeted melatonin photorelease supports the presence of melatonin MT1 receptors in mitochondria inhibiting respiration

Caveats: Requires HV-Compatible Charger: Must be charged using the specific HV charge profile (e.g., "LiHV" mode) set to the correct max voltage (4.35V or 4.45V/cell)