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The first carries meaningful safety risks
For example, aluminum hydroxide salts, often used as vaccine adjuvants, have been found to abnormally persist within immune cells at the site of previous immunization, resulting in macrophagic myofasciitis lesions (168)
doi: 10.1186/s12890-021-01422-9 292 WestA
Additional caution is required in patients with uncontrolled hypertension, recent cardiovascular events, or significant hepatic or renal impairment
Neuroprotective and neurotrophic actions: MC4 signaling is implicated in the regeneration and protection of peripheral nerves, as observed in experimental injury and neuropathy models 3
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