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Since cortisol secretion also follows a regular circadian pattern roughly opposite to that of melatonin, this finding provides additional confirmation of possible day-night cycle disturbance in women with PCOS

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However, it is not an approved antidepressant

Conversations with healthcare providers can be re-framed to discuss What Matters to the patients and caregivers

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They can also use sugar-free gums or lozenges containing xylitol and try gustatory stimulants to aid saliva flow