retatrutide nonalcoholic steatohepatitis trial fatty liver disease nash Retatrutide, the triple G, Glucagon-GIP-GLP-1 based triagonist produces substantial resolution of liver fat #NAFLD in PPL with #obesity #ADA2023 @ADA_DiabetesPro @AmDiabetesAssn #NASH trial coming retatrutide nonalcoholic fatty liver disease

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John reports he has tried all the diets over the years with no lasting improvement, nothing works

Another effect of GLP-1RA is the increase of sympathetic nervous system (SNS) activity

Use of liraglutide 3mg daily in patients with obesity without diabetes was associated with nausea in 40.2% compared to 14.7% in the placebo (68)

In a double blinded placebo-controlled study, weekly injections of retatrutide (12 mg) in obese patients, in conjunction with lifestyle changes, showed average weight decreases of 22.1% over placebo patients after 48 weeks