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contraindicated in pregnancy, breastfeeding, and untreated hypothyroidism, and should be avoided by anyone with active malignancy due to GH's proliferative signaling Stack note: Commonly paired with ipamorelin or GHRP-2 at 200-300 mcg each in the same pre-sleep injection, since GHRH-class peptides (sermorelin) and GHRP-class peptides work through complementary receptor pathways to produce a synergistic GH pulse larger than either compound alone Our take: Sermorelin is the most conservative entry point in this list for anyone who wants growth hormone axis support without the regulatory and physiological risks of exogenous HGH

Researchers can't easily ask someone to take a drug if it might affect the health of their baby, especially when safer options exist

The bedtime timing is physiologically justified because endogenous GH surges occur during slow-wave sleep, and sermorelin amplifies this existing pulse rather than creating a pharmacologically forced one