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While it has not been conclusively established whether this dysfunction is a cause or consequence of the pathological processes, growing evidence suggests that reduced proteasomal activity may contribute to the accumulation of toxic protein aggregates and the progression of neurodegeneration

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Ethics declarations Conflict of interest There are no conflicts of interest between the authors

The results were unambiguous

For the cagrilintide-only arm, registry record NCT05567796 documents 16 weeks of dose escalation then 52 weeks of maintenance, without naming the individual steps

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