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Heparan sulfate proteoglycans in viral infection and treatment: a special focus on SARS-CoV-2

For determining metabolic parameters [O2, CO2, food consumption, respiratory exchange ratio (RER), energy expenditure] and activity tracking, the mice were acclimated to housing in an Oxymax/CLAMS-HC metabolic chamber system (Columbus Instruments) for 24 h and data from a continuous 24 h period was then recorded and analyzed

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Both were placed on FDA Category 2 in September 2023, removed in September 2024 after withdrawn nominations, and reviewed by PCAC in late 2024 with FDA recommending against 503A Bulks inclusion