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In clinical trials, oral semaglutide has demonstrated substantial dose-dependent lowering of both glycated haemoglobin (HbA 1c ) and body weight [15,16,17], with a safety profile in line with other GLP-1RAs [15, 18]

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Although SGLT2is are associated with hemoconcentration, this effect appears to be offset by improvements in inflammation and endothelial function

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Asymptomatic elevations of ammonia are more common and when present, require close monitoring of plasma ammonia levels

This is the question most people avoid asking until they are already on the drug