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This becomes particularly relevant in the context of GLP-1 receptor agonist therapy, where the substantial weight loss these medications produce is not exclusively fat loss
Challenges around muscle loss, long-term adherence, durability of effect, and post-treatment weight regain are increasingly coming into focus
Verdict: Insufficient evidence DSIP does not have convincing human evidence for growth hormone optimization or bodybuilding outcomes [1415]
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Clinical nutrition ESPEN, 63, 417426
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