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an early phase 1b study reported that co-administration was feasible and that each components pharmacokinetics were not meaningfully altered by the other, which motivated the phase 3 program [3]

Hamed DH, Halim RMA, El Attar MM et al (2022) Pulmonary dysfunction in children with cystinosis: single center study

Roles of the enantioselective glutathione S-transferases in cleavage of beta-aryl ether

You are building tissue concentrations and assessing tolerance, not yet achieving therapeutic effects

Compared to the liver, we observed that the kidney has: (1) similar increased use of energy-related metabolites and production of urea cycle and ammonia-related intermediates, suggesting a shared catabolism in AKI, and (2) higher pools of energy metabolism intermediates in AKI

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