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14.9% Mean body weight reduction STEP-1 trial 68 weeks 68 weeks Typical protocol length Titration + maintenance ~85% Patients who reach a measurable weight delta By week 12 lab review PROTOCOL TIMELINE Week 4 Appetite signaling shifts First meaningful behavior change
Genetic insights should be interpreted with a qualified healthcare provider as one data point among many
A 95 , 3446 (2019)
However, its also possible for significant weight loss to improve testosterone levels in men
The trial proceeded without reported toxicity, and no lethal dose threshold (LD1) was ever established in subsequent safety testing meaning researchers administering the compound could not find a dose that caused death in even 1% of test subjects across the animal model safety work that preceded and followed the human study
PLoS ONE 9 , e97330 (2014)
