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Study participants were randomly assigned to either 2.4 mg once weekly subcutaneous semaglutide injection or an equivalent placebo

Participants also recorded reductions in waist circumference (average 7.1cm loss on 6mg, 8.2cm on 12mg, 10cm on 36mg, compared with 3.1cm loss on placebo), blood pressure (estimated -4.2 and -1mm HG difference between placebo and orforglipron in systolic and diatolic blood pressure, respectively) and cholesterol (-2.1% difference between placebo and orforglipron)

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All current use is research-use-only, and the regulatory framing of any material labeled "retatrutide" should reflect that

Patients with certain genetic variants experience less nausea at equivalent doses, while others require slower titration