Furthermore, diagnostics could be a challenge for many PROTAC molecules since target E3 ligases might not necessarily co-express with target proteins in all tissues
Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines
Margolis KG, Li Z, Stevanovic K, Saurman V, Israelyan N, Anderson GM, Snyder I, Veenstra-VanderWeele J, Blakely RD, Gershon MD
However, the pace of oxidant generation can often outstrip the cellular production of glutathione (GSH) which leads to a cascade of oxidative stress, inflammation and tissue damage
PMID: 2995861
Its dysfunction is a central event in the development of obesity