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J-EG-M declares that he has received honoraria for lectures for AstraZeneca, Bayer, Boheringer Ingelheim, Merck, and Xinetixs Pharma
41 A complementary mechanism involves cardiolipin-mediated mitophagy, in which cardiolipin externalizes to the outer mitochondrial membrane and directly interacts with LC3 to trigger mitochondrial turnover
& Bckhed, F
To achieve sustainable weight loss and maintain overall health, it is crucial to integrate GLP-1s into a broader, more holistic approach that includes balanced nutrition, physical activity, and lifestyle changes
For now, patients have access to effective treatments including Wegovy and Zepbound
Given that orally formulated GLP-1 agonists have lower efficacy than injectables, small molecule GLP-1 mimics are expected to make more headway
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