glutathione is an important peptide antioxidant The Amino Company glutathione is it a peptide

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These studies showed that the peptide can reduce the harmful effects of the senescence associated secretory phenotype (SASP)

This is not a conservative precaution

One of the most well-known is Robert's and Szabo's concept of cytoprotection, which holds innate cell (epithelial (Robert), endothelial (Szabo)) integrity, protection/maintenance/reestablishing in the stomach to be translated to other organ therapy (cytoprotectionorganoprotection) via cytoprotection agent's effect

SSRIs, SNRIs, MAOIs, TCAs are hard contraindications even at low topical concentrations.