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Each type of appetite suppressant operates uniquely

A 2021 systematic review of 16 randomized controlled trials and 6,276 participants (Markun and colleagues, Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue, Nutrients, 2021) found that B12 supplementation does not reliably reduce fatigue in people who are not deficient

A standard on/off cycle of 2 months on and 4 weeks off is a commonly used approach

That last area is getting the most attention now

These candidates typically include people who are less able to get B12 naturally from their diet

For the starting dose phase (2 mg per week), 5 mg/mL or 10 mg/mL both work well