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First introduced as an anticonvulsant for the treatment of epilepsy, gabapentins therapeutic scope has expanded considerably due to its efficacy in managing various types of neuropathic pain and other conditions

In patients with MCAS, ongoing mediator release (histamine, prostaglandins, leukotrienes, cytokines) can drive: Visceral hypersensitivity Chronic neuropathic-type pain Heightened itch signaling Sleep disruption Central amplification of sensory input Even when mast cell activity is partially controlled, neural sensitization may persist

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These are topline figures from the company, not the full published data, and retatrutide isnt approved anywhere yet

These changes are associated with faster development of cataracts in knockout mice compared to wild-type mice

But does the reality match the marketing