Step 4: You come in weekly (or as needed), and we adjust things as you go
From early fad diets, through to modern metabolic research, the episode explains why calorie restriction often backfiresand why fueling the body is key to long-term health
instead, decrements are observed
L-carnitine, magnesium lactate, taurine, black carrot juice from concentrate, flavouring, green tea leaf extract Matcha (Camellia sinensis (L.) Kuntze), N-acetyl-L-tyrosine, natural caffeine (from green coffee beans), sweeteners sucralose, acesulfame K
Head-to-Head Comparison: Key Metrics Semaglutide: MW 4113.58 Da | Selective GLP-1 RA | Injectable (weekly) or oral (daily with SNAC) | Mean weight loss 14.9% (STEP 1) | FDA-approved 2021 (obesity) Tirzepatide: MW ~4813.45 Da | Dual GLP-1/GIP | Injectable (weekly) | Mean weight loss 22.5% (SURMOUNT-1) | FDA-approved 2023 (obesity) Retatrutide: MW ~4500 Da | Triple GLP-1/GIP/Glucagon | Injectable (weekly) | Mean weight loss 28.7% (TRIUMPH-4 Phase 3) | Phase 3 as of 2026 Orforglipron: MW 541.65 Da | Selective GLP-1 (non-peptide) | Oral (daily, no food restriction) | Mean weight loss ~14.7% (Phase 3) | FDA-approved April 2026 Receptor Selectivity and Mechanism Differences The four compounds represent a spectrum from single-target to multi-target pharmacology
Accessibility: If you are vision-impaired or have some other impairment covered by the Americans with Disabilities Act or a similar law, and you wish to discuss potential accommodations related to using this website, please contact our Accessibility Manager at (678) 894-9200
