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Leproult R, Van Cauter E

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Elevated cyclic AMP can activate downstream signaling intermediates including protein kinase A and related phosphorylation cascades that regulate gene transcription and cellular metabolic responses

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This may be at room temperature [20-25C (68-77F)] or refrigerated [2-8 C (36 -46 F)]

Application of this model could potentially lead to pioneering strategies to counteract or treat age-related muscle atrophy and impaired regeneration with fibrosis and fat infiltration (including sarcopenia and frailty).