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PMID: 24217090

The study protocol was registered in the International Prospective Register of systematic reviews PROSPERO (CRD420251002447)

The goal is to improve metabolic health in a way that allows individuals to stay active, nourished, and functional, rather than experiencing significant discomfort

Further mechanistic studies have found that treatment with TMZ promoted cardiac Nrf2 expression, indicating that TMZ enhanced the clearance of oxidative stress by activating the GSH system through the Nrf2 signaling pathway [210]

Another study demonstrated effectiveness for binge eating disorder