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Glioma cells upregulate polyamine biosynthesis through ornithine decarboxylase, leading to elevated spermidine levels 15
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doi: 10.3389/fbioe.2025.1729166 Received 21 October 2025 Revised 01 December 2025 Accepted 17 December 2025 Published 15 January 2026 Volume 13 - 2025 Edited by Ling Wang, Dalian Medical University, China Reviewed by Nicola Alessio, University of Campania Luigi Vanvitelli, Italy Yesuf Adem Siraj, Bahir Dar University, Ethiopia Updates Copyright 2026 Hu, Li, Hu, Shan, Tang, Jiang, Yi, Chen, Jin, Wang and Wang
While mechanistically interesting, stacking three or more compounds dramatically increases complexity, cost, and potential for unexpected interactions
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